Novel side reactions accompanying activation and aminolysis of N-benzoyl-2-alkylserines.
نویسندگان
چکیده
منابع مشابه
Novel side reactions accompanying activation and aminolysis of N-benzoyl-2-alkylserines.
2-Phenyl-4-alkyl-4-hydroxymethyl-1,3-oxazolones (2a-d) have been identified as side products accompanying activation of N-benzoyl-2-alkylserines (1a-d). Oxazolones 2a-d in the presence of amine rearrange subsequently to corresponding 4-alkyl-2-phenyl-4,5-dihydro-1,3-oxazole-5 carboxylic acids (4a-d) at a 20-68% yield.
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In the title compound, C(14)H(13)NO(3)S, the conformation of the N-H bond in the C-SO(2)-NH-C(O) segment is anti to the C=O bond. The tolyl and benzoyl groups are twisted about the S-N bond, with a C-S-N-C torsion angle of 68.8 (4)°. The dihedral angle between the sulfonyl and the benzoyl benzene rings is 73.9 (1)°. In the crystal, the mol-ecules are linked into C(4) chains along the c axis by ...
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In the crystal structure of the title compound, C(13)H(10)ClNO(3)S, the conformation of the of the N-H bond in the C-SO(2)-NH-C(O) segment is anti to the C=O bond. The dihedral angle between the two benzene rings is 73.3 (1)°. In the crystal, inversion dimers linked by pairs of N-H⋯O hydrogen bonds occur.
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In the title compound, C(13)H(10)N(2)O(5)S, the N-C bond in the C-SO(2)-NH-C segment has gauche torsion angles with respect to the S=O bonds. The conformation between the N-H bond and the ortho-nitro group in the sulfonyl benzene ring is syn. The mol-ecule is twisted at the S-N bond with a torsion angle of -63.4 (2)°. The sulfonyl benzene ring is tilted by 77.1 (1)° relative to the -SO(2)-NH-C-...
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Toxoplasma gondii is a protozoan parasite that can damage the human brain and eyes. There are no curative medicines. Herein, we describe our discovery of N-benzoyl-2-hydroxybenzamides as a class of compounds effective in the low nanomolar range against T. gondii in vitro and in vivo. Our lead compound, QQ-437, displays robust activity against the parasite and could be useful as a new scaffold f...
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ژورنال
عنوان ژورنال: Acta Biochimica Polonica
سال: 2001
ISSN: 1734-154X,0001-527X
DOI: 10.18388/abp.2001_3887